英文名称：Recombinant Murine Interferon-gamma
产品规格：20μg分子量：Approximately 15.5kDa,a single non-glycosylated polypeptide chain containing 133 amino acids.
储存条件：冷冻（-20℃）概述Interferon-gamma(IFN-γ),also known as Type II interferon or immune interferon,is a cytokine produced primarily by T-lymphocytes and natural killer cells.The protein shares no significant homology with IFN-β or the various IFN-α family proteins.Mature IFN-γ exists as noncovalently-linked homodimers.It shares high sequence indentity with rat IFN-γ(86%).IFN-γ was originally characterized based on its antiviral activities.The protein also exerts antiproliferative,immunoregulatory and proinflammatory activities and is thus important in host defense mechanisms.IFN-γ induces the production of cytokines,upgulates the expssion of class I and II MHC antigens,Fc receptor and leukocyte adhesion molecules.It modulates macrophage effector functions,influences isotype switching and potentiates the secretion of immunoglobulins by B cells.Additionally,IFN-γ augments TH1 cell expansion and may be required for TH1 cell differentiation.使用说明This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.技术规格
|外观||Sterile Filtered White lyophilized(freeze-dried)powder.|
|纯度||＞96%by SDS-PAGE and HPLC analyses.|
|生物活性||Fully biologically active when compared to standard.The ED50 as determined by an anti-viral assay using murine L929 cells infected with encephalomyocarditis(EMC)virus is less than 0.8ng/ml,corresponding to a specific activity of>1.3×106 IU/mg.|
|成分||Lyophilized from a 0.2μmfiltered solution in PBS,pH 7.4,containing 5%trehalose.|
|内毒素||Less than 1 EU/μg of rMuIFN-γ as determined by LAL method.|
|复溶||We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/ml.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.|
|氨基酸序列||HGTVIESLES LNNYFNSSGI DVEEKSLFLD IWRNWQKDGD MKILQSQIIS FYLRLFEVLK DNQAISNNIS VIESHLITTF FSNSKAKKDA FMSIAKFEVN NPQVQRQAFN ELIRVVHQLL PESSLRKRKR SRC|
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Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGFs are generated by proteolytic processing of inactive pcursor proteins, which contains the N- and C-terminal propeptide regions. Mature human IGF-I consisting of 70 amino acids has 94% identity with mouse IGF-I and exhibits cross-species activity. IGF-1 binds IGF-IR, IGF-IIR, and the insulin receptor and plays a key role in cell cycle progression, cell proliferation and tumor progression. IGF-1 expssion is regulated by growth hormone. R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arg (R) f液晶显示器or the Glu(E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. R3 IGF-1 has been produced with the purpose of increasing biological activity. R3 IGF-1 is significantly more potent than human IGF-I in vitro.
- 王女士 销售经理